Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 152
interventional 128
Observational 22
Registry 2

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 60
Biological 11
Biological|Drug 9
Procedure 6
Drug|Procedure 5
Drug|Procedure|Radiation 5
Other 5
Drug|Other|Procedure|Radiation 4
Biological|Drug|Procedure 3
Biological|Drug|Procedure|Radiation 3
Biological|Drug|Radiation 2
Device 2
Device|Drug 2
Drug|placebo 2
Drug|Radiation 2
Biological|Device|Drug|Procedure|Radiation 1
Biological|Device|Drug|Radiation 1
Biological|Drug|Genetic|Other|Procedure 1
Biological|Drug|Other|Procedure|Radiation 1
Device|Other 1
Dietary Supplement 1
Genetic 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 89
China 8
Japan 4
Korea, Republic of 4
NA 4
Egypt 2
France 2
United Kingdom 2
Brazil 1
Brazil|Hong Kong|Hungary|India|Italy|Korea, Republic of|Mexico|Netherlands|Spain|Thailand|Turkey 1
France|Italy|Netherlands|Spain|Switzerland|United Kingdom 1
Germany 1
Italy|Saudi Arabia|United Kingdom 1
Italy|United Kingdom 1
Japan|Korea, Republic of 1
Pakistan 1
Russian Federation 1
Singapore 1
United States|Hong Kong|Netherlands|Portugal|Russian Federation|Thailand|United Kingdom 1
United States|Norway 1
United States|Sweden 1

Sites per Study

Site_count Study_Count
1 99
2 5
3 6
4 2
6 2
7 1
8 1
10 1
11 2
12 2
13 1
22 1
24 1
27 1
29 1
33 1
39 1

Phase

Phase Study_Count
Phase 2 62
Phase 1/Phase 2 18
N/A 16
Phase 1 13
Phase 2/Phase 3 6
Phase 3 6
Phase 4 6
Early Phase 1 1

Number of Arms

Number_of_Arms Count_of_Studies
1 78
2 23
3 6
4 6
7 1
9 1
NA 13

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 25 4.0 8.00000 1.00000 2.00000 14.00000 82.0 20.00000
1st Qu. 25 29.5 12.00000 22.50000 21.00000 27.00000 100.0 52.50000
Median 25 45.0 20.00000 37.50000 39.00000 41.00000 180.0 62.00000
Mean 25 159.5 24.76923 84.27778 58.09836 99.66667 157.6 72.33333
3rd Qu. 25 60.5 37.00000 94.00000 58.00000 98.50000 202.0 106.00000
Max. 25 1732.0 55.00000 500.00000 500.00000 362.00000 224.0 120.00000

Trial Group Type

group_type Group_Count
Experimental 137
Other 29
NA 13
Active Comparator 9
No Intervention 5
Placebo Comparator 2

Intervention Model

intervention_model Study_Count
Single Group Assignment 88
Parallel Assignment 29
NA 9
Crossover Assignment 1
Sequential Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 120
Prevention 4
Supportive Care 3
Other 1

Observational Studies

Studies by Country

Country Study_Count
United States 15
NA 4
Italy 1
Switzerland 1
Taiwan 1

Sites per Study

Site_count Study_Count
1 19
2 1
20 1
144 1

Enrollment Metrics

Measure Observational
Min 7.0
1st Qu 27.5
Median 72.0
Mean 5984.0
3rd Qu 168.0
Max 99999.0

Observation Model

observational_model Study_Count
NA 9
Cohort 8
Case-Only 2
Case-Control 1
Family-Based 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 11
NA 6
Retrospective 3
Other 2

Registries

Studies by Country

Country Study_Count
Spain 1
United States 1

Sites per Study

Site_count Study_Count
1 2

Enrollment Metrics

Measure Registries
Min 50.0
1st Qu 59.5
Median 69.0
Mean 69.0
3rd Qu 78.5
Max 88.0

Registry Model

observational_model Study_Count
Cohort 1
Other 1

Time Perspective

time_perspective Study_Count
Other 1
Prospective 1

Follow-up

target_duration Study_Count
12 Months 1
6 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03394755 Thrombosomes® in Bleeding Thrombocytopenic Patients https://ClinicalTrials.gov/show/NCT03394755 Active, not recruiting Cellphire, Inc. 2019-08-03
NCT01768845 Unrelated Umbilical Cord Blood (UBC)Transplantation https://ClinicalTrials.gov/show/NCT01768845 Active, not recruiting West Virginia University 2019-05-14
NCT03825744 Hetrombopag or Placebo in Treatment-Naive Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT03825744 Recruiting Jiangsu HengRui Medicine Co., Ltd. 2021-02-28
NCT03821987 Risk Stratification Directed Conditioning Regimen for Haploidentical HSCT in SAA https://ClinicalTrials.gov/show/NCT03821987 Recruiting Peking University People’s Hospital 2021-12-30
NCT03333486 Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer https://ClinicalTrials.gov/show/NCT03333486 Recruiting Roswell Park Cancer Institute 2022-09-06
NCT03318159 Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients https://ClinicalTrials.gov/show/NCT03318159 Recruiting Seoul National University Hospital 2019-06-30
NCT03246178 Haploidentical Transplantation in Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT03246178 Enrolling by invitation Chinese PLA General Hospital 2020-07-01
NCT03218657 Clinical Study of Non Severe Aplastic Anemia Treated With Cyclosporine, Androgen and Levamisole https://ClinicalTrials.gov/show/NCT03218657 Recruiting Zhejiang Provincial Hospital of TCM 2019-07-01
NCT03176849 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT https://ClinicalTrials.gov/show/NCT03176849 Enrolling by invitation Phoenix Children’s Hospital 2019-09-01
NCT03173937 Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome https://ClinicalTrials.gov/show/NCT03173937 Recruiting National Institutes of Health Clinical Center (CC) 2021-04-29
NCT03243656 Eltrombopag in Children With Idiopathic Aplastic Anemia https://ClinicalTrials.gov/show/NCT03243656 Recruiting Assiut University 2020-12-31
NCT03025698 A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia https://ClinicalTrials.gov/show/NCT03025698 Recruiting Novartis 2025-04-01
NCT03016806 Umbilical Cord Blood Transplantation From Unrelated Donors https://ClinicalTrials.gov/show/NCT03016806 Recruiting University of Rochester 2025-06-30
NCT02998645 Eltrombopag Combined With Cyclosporine as First Line Therapy in Patients With Severe Acquired Aplastic Anemia https://ClinicalTrials.gov/show/NCT02998645 Recruiting Novartis 2020-11-19
NCT02979873 Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy https://ClinicalTrials.gov/show/NCT02979873 Recruiting National Institutes of Health Clinical Center (CC) 2023-08-31
NCT02960646 Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies https://ClinicalTrials.gov/show/NCT02960646 Recruiting M.D. Anderson Cancer Center 2020-11-30
NCT02928991 Fludarabine Based RIC for Bone Marrow Failure Syndromes https://ClinicalTrials.gov/show/NCT02928991 Recruiting Children’s Hospital of Philadelphia 2020-04-30
NCT02918292 Optimizing Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) https://ClinicalTrials.gov/show/NCT02918292 Recruiting Medical College of Wisconsin 2021-02-28
NCT02875743 King’s Invasive Aspergillosis Study II https://ClinicalTrials.gov/show/NCT02875743 Completed King’s College Hospital NHS Trust 2018-10-31
NCT02845596 Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT02845596 Recruiting Children’s Hospital Los Angeles 2020-05-31
NCT02828592 Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT02828592 Recruiting Northside Hospital, Inc. 2022-08-31
NCT02773290 Study of Romiplostim(AMG531) in Subjects With Aplastic Anemia https://ClinicalTrials.gov/show/NCT02773290 Active, not recruiting Kyowa Kirin Co., Ltd. 2020-12-31
NCT02773225 Efficacy and Safety of Eltrombopag + CSA in Patients With Moderate Aplastic Anemia (EMAA) https://ClinicalTrials.gov/show/NCT02773225 Recruiting University of Ulm 2022-09-30
NCT02745717 The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT02745717 Recruiting Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 2021-12-31
NCT00195624 Alemtuzumab to Treat Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00195624 Completed National Institutes of Health Clinical Center (CC) 2014-04-14
NCT02566304 Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies https://ClinicalTrials.gov/show/NCT02566304 Recruiting Thomas Jefferson University 2020-07-23
NCT02404025 Eltrombopag in Combination With Rabbit Anti-thymocyte Globulin/Cyclosporine A in Naive Aplastic Anemia (AA) Subjects https://ClinicalTrials.gov/show/NCT02404025 Completed Novartis 2016-07-05
NCT02162420 Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT02162420 Recruiting Masonic Cancer Center, University of Minnesota 2024-07-31
NCT02148133 A Study to Assess the Safety and Efficacy of Eltrombopag in Japanese Subjects With Refractory, Moderate or More Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT02148133 Completed Novartis 2015-09-10
NCT02099747 hATG+CsA vs hATG+CsA+Eltrombopag for SAA https://ClinicalTrials.gov/show/NCT02099747 Active, not recruiting European Group for Blood and Marrow Transplantation 2019-09-30
NCT02094417 A Phase 2 Study to Evaluate the Efficacy and Safety of AMG531 in Aplastic Anemia https://ClinicalTrials.gov/show/NCT02094417 Completed Kyowa Kirin Korea Co., Ltd. 2017-04-24
NCT02065869 Safety Study of Gene Modified Donor T-cells Following TCR Alpha Beta Depleted Stem Cell Transplant https://ClinicalTrials.gov/show/NCT02065869 Active, not recruiting Bellicum Pharmaceuticals 2020-08-31
NCT02065154 Post Transplant Cyclophosphamide (Cytoxan) for GvHD Prophylaxis https://ClinicalTrials.gov/show/NCT02065154 Active, not recruiting University of Alabama at Birmingham 2020-04-30
NCT01297972 Mesenchymal Stem Cells in the Treatment of Relapsed/Refractory Severe Acquired Aplastic Anemia https://ClinicalTrials.gov/show/NCT01297972 Completed University of Sao Paulo 2013-11-30
NCT01966367 CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation https://ClinicalTrials.gov/show/NCT01966367 Active, not recruiting Columbia University 2022-01-31
NCT01917708 Bone Marrow Transplant With Abatacept for Non-Malignant Diseases https://ClinicalTrials.gov/show/NCT01917708 Completed Emory University 2019-09-19
NCT01891994 Extended Dosing With Eltrombopag for Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT01891994 Active, not recruiting National Institutes of Health Clinical Center (CC) 2017-10-16
NCT01861093 Safety Study of Cord Blood Units for Stem Cell Transplants https://ClinicalTrials.gov/show/NCT01861093 Recruiting National Institutes of Health Clinical Center (CC) 2037-11-30
NCT01758042 Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders https://ClinicalTrials.gov/show/NCT01758042 Recruiting Massachusetts General Hospital 2019-07-31
NCT01703169 Efficacy and Safety of Eltrombopag In Patients With Severe and Very Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT01703169 Completed University of Utah 2016-06-30
NCT01659606 Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita https://ClinicalTrials.gov/show/NCT01659606 Recruiting Boston Children’s Hospital 2022-12-31
NCT01624805 Methylprednisolone, Horse Anti-Thymocyte Globulin, Cyclosporine, Filgrastim, and/or Pegfilgrastim or Pegfilgrastim Biosimilar in Treating Patients With Aplastic Anemia or Low or Intermediate-Risk Myelodysplastic Syndrome https://ClinicalTrials.gov/show/NCT01624805 Recruiting M.D. Anderson Cancer Center 2020-06-30
NCT01553461 Transplants With Unlicensed Preserved Cord Blood https://ClinicalTrials.gov/show/NCT01553461 Recruiting National Institutes of Health Clinical Center (CC) 2036-10-20
NCT01546415 Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia https://ClinicalTrials.gov/show/NCT01546415 Completed Novartis 2013-11-30
NCT01530555 Prospective Phase II Study of Rabbit Antithymocyte Globulin (ATG, Thymoglobuline®, Genzyme) With Ciclosporin for Patients With Acquired Aplastic Anaemia https://ClinicalTrials.gov/show/NCT01530555 Completed King Faisal Specialist Hospital & Research Center 2013-07-31
NCT01529827 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies https://ClinicalTrials.gov/show/NCT01529827 Completed Roswell Park Cancer Institute 2015-05-28
NCT01499147 Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies https://ClinicalTrials.gov/show/NCT01499147 Completed University of Illinois at Chicago 2013-05-31
NCT01441037 Danazol for Genetic Bone Marrow and Lung Disorders https://ClinicalTrials.gov/show/NCT01441037 Completed National Institutes of Health Clinical Center (CC) 2016-11-14
NCT01384513 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies https://ClinicalTrials.gov/show/NCT01384513 Recruiting Thomas Jefferson University 2020-12-31
NCT01364363 Unrelated Donor Stem Cell Transplantation https://ClinicalTrials.gov/show/NCT01364363 Recruiting Scripps Health 2021-01-31
NCT01362595 Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia https://ClinicalTrials.gov/show/NCT01362595 Active, not recruiting Northwell Health 2018-06-30
NCT01350245 Bone Marrow Transplantation of Patients in Remission Using Partially Matched Relative Donor https://ClinicalTrials.gov/show/NCT01350245 Completed Thomas Jefferson University 2013-05-31
NCT01343953 Cord Blood Transplantation in Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT01343953 Completed Assistance Publique - Hôpitaux de Paris 2017-06-30
NCT01328587 Eltrombopag for Moderate Aplastic Anemia https://ClinicalTrials.gov/show/NCT01328587 Active, not recruiting National Institutes of Health Clinical Center (CC) 2018-03-30
NCT04331483 A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts https://ClinicalTrials.gov/show/NCT04331483 Active, not recruiting Centre Leon Berard 2023-09-30
NCT04304820 Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA) https://ClinicalTrials.gov/show/NCT04304820 Recruiting National Institutes of Health Clinical Center (CC) 2023-03-01
NCT04095936 Study of AMG531 (Romiplostim) in Patients With Aplastic Anemia https://ClinicalTrials.gov/show/NCT04095936 Recruiting Kyowa Kirin Co., Ltd. 2020-12-31
NCT03988608 Study to Assess the Safety and Efficacy of Eltrombopag in Chinese Refractory or Relapsed Severe Aplastic Anemia (SAA) Subjects. https://ClinicalTrials.gov/show/NCT03988608 Recruiting Novartis 2021-08-31
NCT03957694 Study of AMG531(Romiplostim) in Patients With Aplastic Anemia https://ClinicalTrials.gov/show/NCT03957694 Active, not recruiting Kyowa Kirin Co., Ltd. 2020-07-31
NCT03896971 Combination of Thrombopoietin Mimetic and Immunosuppressive Therapy in Aplastic Anaemia https://ClinicalTrials.gov/show/NCT03896971 Recruiting Assiut University 2020-05-01
NCT03904134 Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation https://ClinicalTrials.gov/show/NCT03904134 Recruiting Center for International Blood and Marrow Transplant Research 2024-06-30
NCT03836690 Transfer of Effector Memory T Cells (Tem) Following Allogeneic Stem Cell Transplantation https://ClinicalTrials.gov/show/NCT03836690 Recruiting University College, London 2022-07-01
NCT03733249 Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study https://ClinicalTrials.gov/show/NCT03733249 Enrolling by invitation Bellicum Pharmaceuticals 2034-06-30
NCT03622788 Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant https://ClinicalTrials.gov/show/NCT03622788 Recruiting M.D. Anderson Cancer Center 2021-07-01
NCT03579875 T Cell Receptor α/β TCD HCT in Patients With Fanconi Anemia https://ClinicalTrials.gov/show/NCT03579875 Recruiting Masonic Cancer Center, University of Minnesota 2026-02-28
NCT03557099 A Study to Evaluate the Safety and Efficacy of Hetrombopag Olamine in Severe Aplastic Anemia （SAA） Patient https://ClinicalTrials.gov/show/NCT03557099 Recruiting Jiangsu HengRui Medicine Co., Ltd. 2019-10-31
NCT03531736 T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia https://ClinicalTrials.gov/show/NCT03531736 Recruiting Memorial Sloan Kettering Cancer Center 2021-05-31
NCT03520647 Haplo-Identical Transplantation for Severe Aplastic Anemia and Hypo-Plastic MDS Using Peripheral Blood Stem Cells and Post-Transplant Cyclophosphamide for GVHD Prophylaxis https://ClinicalTrials.gov/show/NCT03520647 Recruiting National Institutes of Health Clinical Center (CC) 2025-06-01
NCT03413306 Eltrombopag+hATG+CsA vs. hATG+CsA in Children With Severe AA https://ClinicalTrials.gov/show/NCT03413306 Recruiting Federal Research Institute of Pediatric Hematology, Oncology and Immunology 2020-10-20
NCT01231841 Anti-thymocyte Globulin and Cyclosporine as First-Line Therapy in Treating Patients With Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT01231841 Completed The Cleveland Clinic 2010-12-31
NCT01224496 Traditional Chinese Medicine in the Supportive Management of Anaemic and Cytopenic (Leukopenia, Thrombocytopenia) Haematological Disorders https://ClinicalTrials.gov/show/NCT01224496 Completed Singapore General Hospital 2011-08-31
NCT01193283 Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT01193283 Completed National Institutes of Health Clinical Center (CC) 2014-09-30
NCT01187017 A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT01187017 Completed National Institutes of Health Clinical Center (CC) 2012-07-31
NCT01105273 Human Leukocyte Antigen (HLA)-Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Aplastic Anemia https://ClinicalTrials.gov/show/NCT01105273 Completed Asan Medical Center 2012-07-31
NCT00997386 Reduced Intensity Allogeneic PBSCT to Treat Hematologic Malignancies and Hematopoietic Failure States https://ClinicalTrials.gov/show/NCT00997386 Completed University of Arizona 2014-04-30
NCT00987480 Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine https://ClinicalTrials.gov/show/NCT00987480 Completed Memorial Sloan Kettering Cancer Center 2017-07-10
NCT00975975 Basiliximab #2: In-Vivo Activated T-Cell Depletion to Prevent Graft-Versus_Host Disease (GVHD) After Nonmyeloablative Allotransplantation for the Treatment of Blood Cancer https://ClinicalTrials.gov/show/NCT00975975 Completed Indiana University 2012-10-31
NCT00944749 Horse ATG/CsA in Aplastic Anemia Patients Unresponsive to or With a Suboptimal Response to Rabbit ATG/CsA Treatment https://ClinicalTrials.gov/show/NCT00944749 Completed National Institutes of Health Clinical Center (CC) 2015-12-31
NCT00922883 A Pilot Study of the Thrombopoietin-Receptor Agonist Eltrombopag in Refractory Aplastic Anemia Patients https://ClinicalTrials.gov/show/NCT00922883 Active, not recruiting National Institutes of Health Clinical Center (CC) 2013-05-07
NCT00856388 Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders https://ClinicalTrials.gov/show/NCT00856388 Completed Roswell Park Cancer Institute 2012-08-09
NCT02833805 NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT02833805 Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2020-08-31
NCT02224872 Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT02224872 Active, not recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2023-11-30
NCT03192397 Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant https://ClinicalTrials.gov/show/NCT03192397 Recruiting Roswell Park Cancer Institute 2021-07-01
NCT01586455 Human Placental-Derived Stem Cell Transplantation https://ClinicalTrials.gov/show/NCT01586455 Active, not recruiting New York Medical College 2019-06-30
NCT00806598 Thymoglobulin and Cyclosporine in Patients With Aplastic Anemia or Myelodysplastic Syndrome https://ClinicalTrials.gov/show/NCT00806598 Completed M.D. Anderson Cancer Center 2012-06-30
NCT01623167 Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT01623167 Recruiting National Institutes of Health Clinical Center (CC) 2018-01-30
NCT01174108 Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells https://ClinicalTrials.gov/show/NCT01174108 Recruiting National Institutes of Health Clinical Center (CC) 2021-06-30
NCT03301168 Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant https://ClinicalTrials.gov/show/NCT03301168 Active, not recruiting Bellicum Pharmaceuticals 2020-02-29
NCT03047746 Unrelated And Partially Matched Related Donor PSCT w/ TCR αβ Depletion for Patients With BMF https://ClinicalTrials.gov/show/NCT03047746 Recruiting Children’s Hospital of Philadelphia 2022-01-31
NCT03955601 A Novel TBI Free Conditioning Protocol for Haploidentical Transplant in Acquired Aplastic Anemia: https://ClinicalTrials.gov/show/NCT03955601 Recruiting National Institute of Blood and Marrow Transplant (NIBMT), Pakistan 2020-12-30
NCT00774527 Comparison of Cy-Atg Vs Cy-Flu-Atg for the Conditioning Therapy in Allo-HCT https://ClinicalTrials.gov/show/NCT00774527 Completed Cooperative Study Group A for Hematology 2010-02-28
NCT00692926 Unrelated Umbilical Cord Blood Transplantation Augmented With ALDHbr Umbilical Cord Blood Cells https://ClinicalTrials.gov/show/NCT00692926 Completed Duke University 2012-07-31
NCT00683046 T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies https://ClinicalTrials.gov/show/NCT00683046 Completed University of Chicago 2014-12-31
NCT00636909 Nonmyeloablative Allo SCT for the Treatment of Hematologic Disorders https://ClinicalTrials.gov/show/NCT00636909 Completed Beth Israel Deaconess Medical Center 2006-03-31
NCT00618969 Peripheral Blood Stem Cell Transplantation (PBSCT)From Haploidentical Related Donors https://ClinicalTrials.gov/show/NCT00618969 Completed University of Arizona 2013-12-31
NCT00604201 Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelopdysplastic Syndrome https://ClinicalTrials.gov/show/NCT00604201 Active, not recruiting National Institutes of Health Clinical Center (CC) 2016-10-25
NCT00578266 Allogeneic Stem Cell Transplantation for Patients With Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00578266 Completed Mayo Clinic 2016-08-16
NCT00533923 Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders https://ClinicalTrials.gov/show/NCT00533923 Completed Beth Israel Deaconess Medical Center 2007-01-31
NCT00516152 Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCT https://ClinicalTrials.gov/show/NCT00516152 Completed University of California, San Francisco NA
NCT00455312 Stem Cell Transplant (SCT) for Dyskeratosis Congenita or SAA https://ClinicalTrials.gov/show/NCT00455312 Completed Masonic Cancer Center, University of Minnesota 2015-03-31
NCT00427336 Purine Analog-Based Conditioning in Patients With Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00427336 Completed M.D. Anderson Cancer Center 2009-08-31
NCT00358657 Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerous Inherited Disorders https://ClinicalTrials.gov/show/NCT00358657 Active, not recruiting Fred Hutchinson Cancer Research Center 2023-12-01
NCT00343785 Cyclophosphamide and Anti-thymocyte Globulin Followed By Methotrexate and Cyclosporine in Preventing Chronic Graft-Versus-Host Disease in Patients With Severe Aplastic Anemia Undergoing Donor Bone Marrow Transplant https://ClinicalTrials.gov/show/NCT00343785 Completed Fred Hutchinson Cancer Research Center 2012-05-31
NCT00326417 Fludarabine-based Conditioning for Severe Aplastic Anemia (BMT CTN 0301) https://ClinicalTrials.gov/show/NCT00326417 Completed Medical College of Wisconsin 2015-09-30
NCT00260689 Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00260689 Completed National Institutes of Health Clinical Center (CC) 2016-05-04
NCT00244010 Partially Matched Stem Cell Transplantation for Patients With Refractory Severe Aplastic Anemia or Refractory Cytopenias https://ClinicalTrials.gov/show/NCT00244010 Completed St. Jude Children’s Research Hospital 2008-11-30
NCT00243399 Oxandrolone for the Treatment of Bone Marrow Aplasia in Fanconi Anemia https://ClinicalTrials.gov/show/NCT00243399 Completed Children’s Hospital Medical Center, Cincinnati 2009-12-31
NCT00229619 Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia https://ClinicalTrials.gov/show/NCT00229619 Completed National Institutes of Health Clinical Center (CC) 2010-06-30
NCT00186797 Purified CD34+ Hematopoietic Stem Cell Transplantation From Alternate Donors for Patients With Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00186797 Completed St. Jude Children’s Research Hospital 2005-09-30
NCT00144729 Conditioning Regimens for Patients With Severe Aplastic Anemia Transplanted With Marrow From an Unrelated Donor https://ClinicalTrials.gov/show/NCT00144729 Completed Fred Hutchinson Cancer Research Center NA
NCT00065260 Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00065260 Completed National Institutes of Health Clinical Center (CC) 2014-12-31
NCT00061763 Study of Deferasirox in Iron Overload From Beta-thalassemia Unable to be Treated With Deferoxamine or Chronic Anemias https://ClinicalTrials.gov/show/NCT00061763 Completed Novartis 2004-11-30
NCT00061360 Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00061360 Completed National Institutes of Health Clinical Center (CC) 2005-11-15
NCT00054236 Combination Chemotherapy Followed By Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00054236 Completed Case Comprehensive Cancer Center 2011-03-31
NCT00053989 NMA Allogeneic Hematopoietic Cell Transplant in Hematologic Cancer/Disorders https://ClinicalTrials.gov/show/NCT00053989 Completed Roswell Park Cancer Institute 2018-07-19
NCT00004143 Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes https://ClinicalTrials.gov/show/NCT00004143 Completed Duke University 2008-05-31
NCT00003816 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer https://ClinicalTrials.gov/show/NCT00003816 Completed Roswell Park Cancer Institute 2019-07-12
NCT00673114 Unrelated Cord Blood Transplant Plus a Haplo-Identical (Half-Matched), T-Cell Depleted Stem Transplant From a Related Donor for Subjects With High Risk Malignancies https://ClinicalTrials.gov/show/NCT00673114 Completed Duke University 2012-04-30
NCT00011830 Stem Cell Mobilization Potential in Patients With Aplastic Anemia in Remission https://ClinicalTrials.gov/show/NCT00011830 Completed National Institutes of Health Clinical Center (CC) NA
NCT00005935 Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia https://ClinicalTrials.gov/show/NCT00005935 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001964 Combination Therapy of Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00001964 Completed National Institutes of Health Clinical Center (CC) 2003-12-09
NCT00001626 Comparing Therapies for the Treatment of Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT00001626 Completed National Institutes of Health Clinical Center (CC) 2001-02-20
NCT00001398 Stem Cell Factor Medication for Aplastic Anemia https://ClinicalTrials.gov/show/NCT00001398 Completed National Institutes of Health Clinical Center (CC) NA
NCT00000603 Cord Blood Stem Cell Transplantation Study (COBLT) https://ClinicalTrials.gov/show/NCT00000603 Completed National Heart, Lung, and Blood Institute (NHLBI) 2007-10-31
NCT00000597 Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders https://ClinicalTrials.gov/show/NCT00000597 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00004474 Phase III Randomized Study of Cyclophosphamide With or Without Antithymocyte Globulin Before Bone Marrow Transplantation in Patients With Aplastic Anemia https://ClinicalTrials.gov/show/NCT00004474 Completed Office of Rare Diseases (ORD) 2007-08-31
NCT00004464 Study of High Dose Cyclophosphamide in Patients With Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria https://ClinicalTrials.gov/show/NCT00004464 Completed Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2007-03-01
NCT00004323 Phase II Study of Bone Marrow Transplantation Using Related Donors in Patients With Aplastic Anemia https://ClinicalTrials.gov/show/NCT00004323 Completed National Center for Research Resources (NCRR) NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03208647 Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia https://ClinicalTrials.gov/show/NCT03208647 Completed Zhejiang Provincial Hospital of TCM 2014-01-01
NCT04436380 Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy https://ClinicalTrials.gov/show/NCT04436380 Active, not recruiting National Institutes of Health Clinical Center (CC) 2021-04-22
NCT01351545 A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) https://ClinicalTrials.gov/show/NCT01351545 Recruiting Center for International Blood and Marrow Transplant Research 2021-10-31
NCT00050115 Collection of Biological Samples From Patients With Hepatitis-Associated Aplastic Anemia https://ClinicalTrials.gov/show/NCT00050115 Completed National Institutes of Health Clinical Center (CC) NA
NCT02225145 Fertility Preservation in Women Who Will Have Gonadotoxic Therapy or Hematopoetic Stem Cell Transplantation, and in Women With Sickle Cell Disease https://ClinicalTrials.gov/show/NCT02225145 Completed National Institutes of Health Clinical Center (CC) 2016-09-09
NCT01956799 Identification of Mechanism in the Erythroid Response in Patients With Myelodysplasia Undergoing Chelation Therapy https://ClinicalTrials.gov/show/NCT01956799 Active, not recruiting Fondazione Italiana Sindromi Mielodisplastiche Onlus 2018-07-31
NCT01900119 A Description of Bacteria in the Mouths of Patients With Severe Aplastic Anemia https://ClinicalTrials.gov/show/NCT01900119 Completed National Institutes of Health Clinical Center (CC) 2016-07-05
NCT04436367 Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7Abnormalities After Immunosuppressive Therapy https://ClinicalTrials.gov/show/NCT04436367 Active, not recruiting National Institutes of Health Clinical Center (CC) 2021-04-22
NCT04128943 Electronic Patient-reported Outcome Monitoring in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria https://ClinicalTrials.gov/show/NCT04128943 Active, not recruiting University Hospital, Basel, Switzerland 2020-06-30
NCT04060485 Screening Gene Mutations in Myeloid Cancers by Next Generation Sequencing to Improve Treatment Results https://ClinicalTrials.gov/show/NCT04060485 Recruiting National Taiwan University Hospital 2024-08-31
NCT01241357 High-Tc Susceptometer to Monitor Transfusional Iron Overload https://ClinicalTrials.gov/show/NCT01241357 Completed Columbia University 2015-10-31
NCT01199562 Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant https://ClinicalTrials.gov/show/NCT01199562 Completed City of Hope Medical Center 2013-12-31
NCT00993694 Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone https://ClinicalTrials.gov/show/NCT00993694 Completed Vanderbilt University Medical Center 2009-12-31
NCT00767650 Neuropsychological Effects of Immunosuppressive Treatment in Subjects With Aplastic Anemia https://ClinicalTrials.gov/show/NCT00767650 Completed National Institutes of Health Clinical Center (CC) NA
NCT00569842 Investigation of the Cylex® ImmuKnow® Assay https://ClinicalTrials.gov/show/NCT00569842 Completed Indiana University 2010-02-28
NCT00513175 Non-Myeloablative Allogeneic Stem Cell Transplantation With Matched Unrelated Donors for Treatment of Hematologic Malignancies, Renal Cell Carcinoma, and Aplastic Anemia https://ClinicalTrials.gov/show/NCT00513175 Completed University of California, San Francisco NA
NCT00027274 Cancer in Inherited Bone Marrow Failure Syndromes https://ClinicalTrials.gov/show/NCT00027274 Recruiting National Institutes of Health Clinical Center (CC) NA
NCT00011453 Protection Against Benzene Toxicity https://ClinicalTrials.gov/show/NCT00011453 Completed National Institute of Environmental Health Sciences (NIEHS) NA
NCT00006300 Oral Manifestations of Aplastic Anemia https://ClinicalTrials.gov/show/NCT00006300 Completed National Institutes of Health Clinical Center (CC) NA
NCT00005682 Aplastic Anemia Epidemiology: Incidence and Case-control https://ClinicalTrials.gov/show/NCT00005682 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00005307 Etiology of Blood Dyscrasias: Analysis of the International Agranulocytosis and Aplastic Anemia Study Data https://ClinicalTrials.gov/show/NCT00005307 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00005302 Drug Etiology of Aplastic Anemia and Related Dyscrasias https://ClinicalTrials.gov/show/NCT00005302 Completed National Heart, Lung, and Blood Institute (NHLBI) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT01933035 Extended Platelet Parameters as a Means to Differentiate Immune Thrombocytopenia From Hypo-proliferative Thrombocytopenias. https://ClinicalTrials.gov/show/NCT01933035 Completed Beth Israel Medical Center 2015-10-31
NCT04001686 Ambispective Observational Study to Evaluate the Incidence and Management of Aplastic Anemia in Spain https://ClinicalTrials.gov/show/NCT04001686 Recruiting Asociacion Instituto Biodonostia 2019-07-30